Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex
نویسندگان
چکیده
منابع مشابه
Efficient Process Development of Recombinant Human Granulocyte Colony-Stimulating Factor (rh-GCSF) Production in Escherichia coli
Background: The protein hormone granulocyte colony-stimulating factor (GCSF) stimulates the production of white blood cells and plays an important role in medical treatment of cancer patients. Methods: An efficient process was developed for heterologous expression of human GCSF in E. coli BL21 (DE3). The feeding rate was adjusted to achieve the maximum attainable specific growth rate under crit...
متن کاملExpression of granulocyte colony stimulating factor (GCSF) in Hansenula polymorpha
BACKGROUND AND OBJECTIVES During past decades Hansenula polymorpha has attracted global attention for the expression of recombinant proteins due to its high growth rate, minimal nutritional porequirements and use of methanol as a low cost inducer. MATERIALS AND METHODS The corresponding nucleotide sequences for the expression of heterologous genes in Hansenula poylmorpha were extracted and as...
متن کاملexpression of granulocyte colony stimulating factor (gcsf) in hansenula polymorpha
background and objectives: during past decades hansenula polymorpha has attracted global attention for the expression of recombinant proteins due to its high growth rate, minimal nutritional porequirements and use of methanol as a low cost inducer. materials and methods: the corresponding nucleotide sequences for the expression of heterologous genes in hansenula poylmorpha were extracted and as...
متن کاملefficient process development of recombinant human granulocyte colony-stimulating factor (rh-gcsf) production in escherichia coli
background: the protein hormone granulocyte colony-stimulating factor (gcsf) stimulates the production of white blood cells and plays an important role in medical treatment of cancer patients. methods: an efficient process was developed for heterologous expression of human gcsf in e. coli bl21 (de3). the feeding rate was adjusted to achieve the maximum attainable specific growth rate under crit...
متن کاملThe laminin receptor modulates granulocyte-macrophage colony-stimulating factor receptor complex formation and modulates its signaling.
Basement membrane matrix proteins are known to up-regulate granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling in neutrophils and mononuclear phagocytes, but the mechanisms involved are poorly understood. We used the intracellular portion of the alpha subunit of the GM-CSF receptor (alphaGMR) to search for interacting proteins and identified the 67-kDa laminin receptor (LR), a n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0511264103